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Some diploma of immunophenotype overlap amid CLL, marginal zone lymphoma, and lymphoplasmacytic lymphoma exists. If the prognosis is uncertain dependant on peripheral blood stream cytometry, lymph node biopsy must be pursued.
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forty four Also, anergic cells Ordinarily keep a better susceptibility to apoptosis Except anti-apoptotic proteins for instance BCL2 are overexpressed, as is the situation for CLL cells.45 In truth, most big therapeutic improvements developing in the last 10 years are related to the inhibition of BCR and BCL2-mediated signaling.
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